SIFI (solvent induced in-situ forming implant) has received remarkable interest in implant technology over last few decades. SIFI offer a number of advantages over solid implant and microspheric depot. SIFI is an amazing invention which forms an implant after coming in contact with the body fluids upon injection and offer other advantages like sustained drug delivery, improved patient compliance, non invasive application, localized drug delivery, reduced side effects, increased drug loading and simple manufacturing process. This review discuss the various components of SIFI formulation, mechanism of in-situ implant formation, various aspects of sterilization, biocompatibility, stability, various patents and pharmaceutical application using SIFI technology. Though the SIFI technology provides a lot of advantages it do suffer from disadvantages like burst effect, toxicity of organic solvent and lack of toxicity data. New polymer combination, solvent, solvent combination, additives are being investigated to address the problems associated with SIFI. But it can be predicted that this technology will gain further significance in the field of implant technology in the coming years.
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